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Common Human Antibiotic Can Heal Coral Disease with 95% Success Rate

Source: GoodNewsNetwork

Amoxicillin—an antibiotic commonly used to treat bacterial infections in humans—is showing promise in treating stony coral tissue loss disease (SCTL).

Common antibiotic effective in healing coral disease lesions

Amoxicillin, a common antibiotic used to treat bacterial infections in humans is showing promise in treating stony coral, found throughout the tropical western Atlantic, including several areas currently affected by stony coral tissue loss (SCTL) disease. Preserving Montastraea cavernosa colonies is important due to its high abundance and role as a dominant reef builder in the northern section of Florida’s Coral Reef. Results show that the Base 2B plus amoxicillin treatment had a 95% success rate at healing individual disease lesions.

(a) Diver creating a trench around the SCTLD lesion using an angle grinder. (b) Filling a trench with the chlorinated epoxy treatment. (c) Filling a trench with the Base 2B plus amoxicillin mixture. (d) A SCTLD-affected coral colony that has been treated with the Base 2B plus amoxicillin mixture. (e) A SCTLD-affected coral colony partially treated with the chlorinated epoxy.
Step-by-step process of treating SCTLD-affected coral colonies in situ: (a) Diver creating a trench around the SCTLD lesion using an angle grinder. (b) Filling a trench with the chlorinated epoxy treatment. (c) Filling a trench with the Base 2B plus amoxicillin mixture. (d) A SCTLD-affected coral colony that has been treated with the Base 2B plus amoxicillin mixture. (e) A SCTLD-affected coral colony partially treated with the chlorinated epoxy. Source: Nature.com

amoxicillin treatment had a 95% success rate at healing individual disease lesions

Diseases continue to be a major threat to coral reef health, but a new study by Florida researchers reveals how a common antibiotic used to treat bacterial infections in humans is showing great promise.

A recent outbreak of an infectious disease called stony coral tissue loss has affected 20 different stony coral species. First discovered in 2014 in Miami-Dade County, the disease has spread throughout Florida’s Coral Reef and into parts of the Caribbean.

In treating disease-affected Montastraea cavernosa coral colonies (the Great Star Coral widely found in the Atlantic), the Harbor Branch Oceanographic Institute of Florida Atlantic University found that an amoxicillin treatment had a 95% success rate at healing individual disease lesions.

Though, it did not necessarily prevent treated colonies from developing new lesions over time, preserving M. cavernosa colonies is important due to its role as a dominant reef builder in Florida’s Coral Reef.

“There are three possible scenarios that may explain the appearance of new lesions in the amoxicillin treated lesions of the corals that had healed in our study,” said Erin N. Shilling, M.S., the study‘s author.

“It’s possible that the causative agent of stony coral tissue loss disease is still present in the environment and is re-infecting quiesced colonies. It also could be that the duration and dose of this antibiotic intervention was sufficient to arrest stony coral tissue loss, but insufficient at eliminating its pathogens from other areas of the coral colony.”

Source: GoodNewsNetwork 

3a & 3b show a Base 2B plus amoxicillin treated colony (a) immediately after treatment application and (b) 46 weeks after treatment, with almost all initial coral tissue remaining. 3c & 3d show a representative chlorinated epoxy treated M. cavernosa colony (c) immediately after treatment and (d) nine weeks after treatment, with the lesions progressing across the trench.
Examples of treated Montastraea cavernosa coral colonies with and without tissue remaining between trenched areas and the initial disease margin: 3a & 3b show a Base 2B plus amoxicillin treated colony (a) immediately after treatment application and (b) 46 weeks after treatment, with almost all initial coral tissue remaining. 3c & 3d show a representative chlorinated epoxy treated M. cavernosa colony (c) immediately after treatment and (d) nine weeks after treatment, with the lesions progressing across the trench. Source: Nature.com

Success in treating coral with antibiotics typically used against bacterial infections in humans

“Success in treating stony coral tissue loss disease with antibiotics may benefit from using approaches typically successful against bacterial infections in humans—for example using a strong initial dose of antibiotics followed by a regimen of smaller supplementary doses over time,” said Joshua Voss, Ph.D., senior author, an associate research professor at FAU Harbor Branch and executive director of the NOAA Cooperative Institute for Ocean Exploration, Research, and Technology.

“Further efforts are needed to optimise dosing and delivery methods for antibiotic treatments…and scale up intervention treatments effectively.”

The study was conducted approximately 2 kilometers offshore from Lauderdale-by-the-Sea in Broward County. Colonies were monitored periodically over 11 months..

This research is a collaboration that includes the Disease Advisory Committee (DAC) organised by the Florida Department of Environmental Protection and NOAA, of which Voss and Shilling are members.

The study, published in Scientific Reports, was funded by the Florida Department of Environmental Protection, the Environmental Protection Agency, and the Harbor Branch Oceanographic Institute Foundation.

Source: GoodNewsNetwork 

Joshua Voss PhD –FAU Harbor Branch, Coral Reef and Health Ecology Lab: “Success in treating stony coral tissue loss disease with antibiotics may benefit from using approaches typically successful against bacterial infections in humans, for example using a strong initial dose of antibiotics followed by a regimen of smaller supplementary doses over time,” Source: GoodNewsNetwork
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